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Traumatic Brain Injury PART TWO: Biomarkers for Traumatic Brain Injury and Applications in Pediatrics
Release and Expiration Dates
Released: 4.11.2025
Expires: 4.10.2028
Last Reviewed Date
4.11.2025
Traumatic Brain Injury PART TWO: Biomarkers for Traumatic Brain Injury and Applications in Pediatrics

Description:

According to the CDC, in 2021, there were more than 586 TBI-related hospitalizations and 190 TBI-related deaths per day. These numbers do not include concussions or mild TBIs that were discharged from the emergency department. According to Schneider (2021), approximately 47.4% of individuals over the age of 40 have a history of TBI and are living with a disability.

Based on evaluation data from the TCAA’s on-demand learning system, many healthcare providers have requested additional education on TBIs. In response, TCAA’s Education Committee has developed a nine-part series covering the continuum of care, from EMS to discharge to the community. The series will conclude with a session on coding TBI-related injuries. Each webinar will feature healthcare providers from across the United States.

Objectives:

  • Review available and potential biomarkers for traumatic brain injury
  • Review pivotal studies leading to FDA approval of GFAP and UCH-L1 for mild TBI in adults
  • Review past and on-going studies for use of biomarkers for TBI in pediatric population

Moderator: Kim Barre  
Presenter: Dr. Grace Lai

Bio: Dr. Lai is a Pediatric Neurosurgeon at Children's Nebraska. She is originally from the East Coast where she completed her undergraduate and PhD in child development and developmental neuroscience at Cornell and Columbia University. She went to medical school at the University of California San Diego, residency in Neurosurgery at Northwestern University, and fellowship in Pediatric Neurosurgery at the University of California San Francisco.
References
  • Kuppermann, N., Holmes, J. F., Dayan, P. S., Hoyle, J. D., Atabaki, S. M., Holubkov, R., Nadel, F. M., Monroe, D., Stanley, R. M., Borgialli, D. A., Badawy, M. K., Schunk, J. E., Quayle, K. S., Mahajan, P., Lichenstein, R., Lillis, K. A., Tunik, M. G., Jacobs, E. S., Callahan, J. M., Gorelick, M. H., Glass, T. F., Lee, L. K., Bachman, M. C., Cooper, A., Powell, E. C., Gerardi, M. J., Melville, K. A., Muizelaar, J. P., Wisner, D. H., Zuspan, S. J., Dean, J. M., Wootton-Gorges, S. L., & Pediatric Emergency Care Applied Research Network (PECARN).  (2009). Identification of children at very low risk of clinically important brain injuries after head trauma: A prospective cohort study.  The Lancet, 374(9696), 1160–1170. https://doi.org/10.1016/S0140-6736(09)61558-0
  • Burstein, B., Terra, F., Upton, J., Neuman, M. Use of CT for head trauma: 2007–2015. Pediatrics, 142(4), e20180814
     
    https://doi.org/10.1542/peds.2018-0814
  • Lyons, T., Mannix, R., Monuteaux, M. Schutzman, Emergency department evaluation of young infants with suspected sepsis: A prospective cohort study. Pediatrics, 153(6), e2023065037.
    https://doi.org/10.1542/peds.2023-065037
  • Knighton, A. J., Wolfe, D., Hunt, A., Neeley, A., Shrestha, N., Hess, S., Hellewell, J., Snow, G., Srivastava, R., Nelson, D., & Schunk, J. E. (2022). Improving head CT scan decisions for pediatric minor head trauma in general emergency departments: A pragmatic implementation study. Pediatrics, 80(4), 332-343.
  • Bazarian, J. J., Biberthaler, P., Welch, R. D., Lewis, L. M., Barzo, P., Bogner-Flatz, V., Brolinson, P. G., Büki, A., Chen, J. Y., Christenson, R. H., Hack, D., Huff, J. S., Johar, S., Jordan, J. D., Leidel, B. A., Lindner, T., Ludington, E., Okonkwo, D. O., Ornato, J., Peacock, W. F., Schmidt, K., Tyndall, J. A., Vossough, A., & Jagoda, A. S. (2018). Serum GFAP and UCH-L1 for prediction of absence of intracranial injuries on head CT (ALERT-TBI): A multicentre observational study. Journal of Neurotrauma, 17(9), 782-789. https://doi.org/10.1089/neu.2018.581
  • Czeiter, E., Amrein, K., Gravesteijn, B. Y., Lecky, F., Menon, D. K., Mondello, S., Newcombe, V. F. J., Richter, S., Steyerberg, E. W., Vande Vyvere, T., Verheyden, J., Xu, H., Yang, Z., Maas, A. I. R., Wang, K. K. W., Büki, A., & CENTER-TBI Participants and Investigators. (2020). Blood biomarkers on admission in acute traumatic brain injury: Relations to severity, CT findings, and care path in the CENTER-TBI study. BioMedicine, 56, 102785. https://doi.org/10.1016/j.ebiom.2020.102785
  • Metting, Z., Wilczak, N., Rodiger, L. A., Schaaf, J. M., & van der Naalt, J. (2012). GFAP and S100B in the acute phase of mild traumatic brain injury. Neurology, 78(18), 1428-1433. https://doi.org/10.1212/WNL.0b013e318253d5c7
Summary
Availability: On-Demand
Cost: FREE
Credit Offered:
1 CE Credit
1 COP Credit
1 TCAA CME Credit
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